AI Article Synopsis
- The CCR4-NOT complex is a key gene silencer that helps regulate mRNA through processes like translation repression and mRNA decay, mainly by interacting with regulatory proteins and microRNAs.
- Recent findings indicate that the CCR4-NOT complex can repress translation and facilitate mRNA degradation even without a poly(A) tail, showcasing its versatility in gene regulation.
- Additionally, the complex has E3 ubiquitin ligase activity, contributing to a new protein quality control system that targets faulty proteins for degradation during translation.
Article Abstract
The CCR4-NOT complex is a highly conserved specific gene silencer that also serves more general post-transcriptional functions. Specific regulatory proteins including the miRNA-induced silencing complex and its associated proteins, bind to 3'-UTR elements of mRNA and recruit the CCR4-NOT complex thereby promoting poly(A) shortening and repressing translation and/or mRNA degradation. Recent studies have shown that the CCR4-NOT complex that is tethered to mRNA by such regulator(s) represses translation and facilitates mRNA decay independent of a poly(A) tail and its shortening. In addition to deadenylase activity, the CCR4-NOT complex also has an E3 ubiquitin ligase activity and is involved in a novel protein quality control system, i.e., co-translational proteasomal-degradation of aberrant proteins. In this review, we describe recent progress in elucidation of novel roles of the multi-functional complex CCR4-NOT in post-transcriptional regulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033010 | PMC |
| http://dx.doi.org/10.3389/fgene.2014.00135 | DOI Listing |
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