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Background/aims: In recent years, a great interest has been dedicated to the development of noninvasive predictive models to substitute liver biopsy for cirrhosis assessment and follow-up. Our aim was to provide a simple marker for predicting liver cirrhosis in chronic hepatitis B virus (HBV)-infected patients based on routinely available clinical parameters.
Methodology: Three hundred and fifty-four patients with chronic hepatitis B, including 144 with cirrhosis, 210 without cirrhosis, and 68 healthy controls were enrolled in the study. During the study, a blood sample was collected from all cases to examine liver function, renal function, international normalized ratio (INR) and routine hematological testing.
Results: We demonstrated that in the cirrhosis group, mean platelet volume (MPV) values were significantly increased compared with healthy controls and non-cirrhosis group. Multivariate analysis demonstrated that MPV, total bilirubin (TB) and INR were independent predictors for cirrhosis (both P < 0.01).
Conclusions: MPV is a simple and non-invasive routine laboratory parameters and elevated MPV level might be an independent predictor for cirrhosis in patients with chronic HBV infection.
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