Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B12 derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the catalytic domain of sGC and show higher activity than (CN)2Cbi.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025757 | PMC |
| http://dx.doi.org/10.1021/ml300060n | DOI Listing |
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