We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango β-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025658 | PMC |
| http://dx.doi.org/10.1021/ml2003058 | DOI Listing |
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