We report the development and characterization of compound 22 (MK-5046), a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3). In pharmacological testing using diet-induced obese mice, compound 22 caused mechanism-based, dose-dependent reductions in food intake and body weight.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018145 | PMC |
| http://dx.doi.org/10.1021/ml100196d | DOI Listing |
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