Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007831 | PMC |
| http://dx.doi.org/10.1021/ml100081e | DOI Listing |
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