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Simultaneous blockade of the CD73/EGFR axis inhibits tumor growth.
IUBMB Life
January 2025
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Targeting the influencing factors in tumor growth and expansion in the tumor microenvironment is one of the key approaches to cancer immunotherapy. Various factors in the tumor microenvironment can in cooperation stimulate tumor growth, suppress anti-tumor immune responses, promote drug resistance, and ultimately enhance tumor recurrence. Therefore, due to the dependence and close cooperation of these axes, their combined targeting can have a greater effect compared to their individual targeting.
View Article and Find Full Text PDFUpregulation of LncRNAs G2E3-AS1 and BACE1-AS as Prognostic Biomarkers in Metastatic Colorectal Cancer.
Biomarkers
January 2025
Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Background: Despite the current diagnostic techniques and therapeutic methods for colorectal cancer (CRC), patients are often diagnosed at advanced stages of colorectal cancer with poor prognosis and distant metastasis. Recently, numerous investigations have highlighted the crucial role of lncRNAs in cancer development, progression, invasion, and metastasis. This study investigated less well-characterized genes in the colorectal cancer metastasis process using bioinformatics analysis and their confirmation by experimental methods.
View Article and Find Full Text PDFPimenov: A potent antifungal medicinal plant.
Curr Med Mycol
May 2024
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Background And Purpose: species are well-known antifungal medicinal plants. (Apiaceae family) is a rarely investigated plant endemic to Iran. The present study aimed to assess the antifungal, antibacterial, antioxidant, and cytotoxic activities of root extracts of different plants.
View Article and Find Full Text PDFExosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen therapy enhance neuroregeneration in a rat model of sciatic nerve crush injury.
Regen Ther
March 2025
Cellular and Molecular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Peripheral nerve damage continues to be a significant challenge in the field of medicine, with no currently available effective treatment. Currently, we investigated the beneficial effects of human placenta mesenchymal stem cells (PMSCs)- derived exosomes along with hyperbaric oxygen therapy (HBOT) in a sciatic nerve injury model. Seventy-five male mature Sprague-Dawley rats were allocated into five equal groups.
View Article and Find Full Text PDFA review of cell-free DNA and epigenetics for non-invasive diagnosis in solid organ transplantation.
Front Transplant
November 2024
Aix-Marseille University, Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang (EFS), Anthropologie Bio-Culturelle, Droit, Éthique et Santé (ADES), Marseille, France.
Article Synopsis
- Circulating cell-free DNA (cfDNA) is a promising non-invasive biomarker for monitoring solid organ transplantation (SOT), with increased research showcasing its diagnostic potential, especially regarding transplant rejection.
- A systematic review of 40 studies revealed that levels of donor-derived cfDNA (dd-cfDNA) rise significantly during rejection episodes and can help distinguish between rejection and non-rejection in different transplanted organs.
- Despite its promise, cfDNA measurement still requires standardization in technology and protocols to improve diagnostic accuracy and specificity, potentially enhanced by incorporating epigenetic analyses.
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