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Equalization of basic public services enabled by digitization: A study of mechanism and heterogeneity.
PLoS One
January 2025
School of Finance, Lanzhou University of Finance and Economics, Lanzhou, PR China.
Digitalization has penetrated into every aspect of life. However, research on the mechanisms through which digitalization affects the equalization of basic public services, as well as the heterogeneity of its impact on different fields of these services, is still insufficient. Based on the panel data of 30 provincial-level administrative regions in China from 2013 to 2023, this paper studies the mechanism and heterogeneity of the impact of digital development on the equalization of basic public services.
View Article and Find Full Text PDFContinuity of Mitochondrial Budding: Insights from BS-C-1 Cells by In Situ Cryo-electron Tomography.
Microsc Microanal
January 2025
The Laboratory for Biomolecular Structures, Brookhaven National Laboratory, Upton, NY 11973, USA.
Mitochondrial division is a fundamental biological process essensial for cellular functionality and vitality. The prevailing hypothesis that dynamin related protein 1 (Drp1) provides principal control in mitochondrial division, in which it also involves the endoplasmic reticulum (ER) and the cytoskeleton, does not account for all the observations. Therefore.
View Article and Find Full Text PDFInformal care for people with dementia in Europe.
J Prev Alzheimers Dis
January 2025
Division of Neurogeriatrics, Department of Neurobiology Care Sciences and Society; Karolinska Institutet; Sweden; BioClinicum J9:20, Akademiska stråket, 171 64 Solna, Sweden.
Introduction: Informal care estimates for use in health-economic models are lacking. We aimed to estimate the association between informal care time and dementia symptoms across Europe.
Methods: A secondary analysis was performed on 13,529 observations in 5,369 persons from 9 European pooled cohort or trial studies in community-dwelling persons with dementia.
Identification of clinicopathological-specific driver gene and genetic subtyping of colorectal cancer.
Cancer Sci
January 2025
Department of colorectal surgery, The First Affiliated Hospital of Ningbo University, Ningbo, China.
This study analyzed targeted sequencing data from 6530 tissue samples from patients with metastatic Chinese colorectal cancer (CRC) to identify low mutation frequency and subgroup-specific driver genes, using three algorithms for overall CRC as well as across different clinicopathological subgroups. We analyzed 425 cancer-related genes, identifying 101 potential driver genes, including 36 novel to CRC. Notably, some genes demonstrated subgroup specificity; for instance, ERBB4 was found as a male-specific driver gene and mutations of ERBB4 only influenced the prognosis of male patients with CRC.
View Article and Find Full Text PDFExperimental Study on the Elastic Support in a Discrete Rail Fastening System Used in Ballastless Tram Track Structures.
Materials (Basel)
January 2025
Faculty of Civil Engineering, Warsaw University of Technology, Al. Armii Ludowej 16, 00-637 Warsaw, Poland.
This paper presents an experimental study on the elastic support in a discrete rail fastening system used in a ballastless tram track structure. The study focuses on the elastic support of the anchor element, specifically the Pm49 baseplate. These elements significantly influence environmental pollution along tram routes, such as vibration (at low frequencies) or noise (at high frequencies), as well as static and dynamic rail deflections.
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