Four groups of 10 male rats (Group A: normal rats, Group B: castrated rats, Group C: castrated rats + 1 mg P.T./day, Group D: castrated rats + 1 dose of 50 mg/kg of P.T. cyclohexane) were avoidance conditioned during nine sessions of 50 trials. They were conditioned individually during sessions 4, 5 and 6 and by pairs during sessions 1, 2, 3, 7, 8 and 9. During these last sessions, all groups presented a low level of acquisition and aggressive behaviour. These phenomena were worsened in the castrated rats whose performances stayed low even when they were conditioned individually. On the other hand, the frequency of their aggressive behaviour was often higher than that of the other groups. The injection of P.T. cyclo-hexane improves the performance of the castrated animals but does not entirely compensate for the differences between control and experimental rats.
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http://dx.doi.org/10.1016/0376-6357(77)90005-5 | DOI Listing |
Biol Pharm Bull
January 2025
Division of Bio-Analytical Chemistry, Faculty of Medical Technology, Niigata University of Pharmacy and Medical and Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan.
Postmenopausal women are at a higher risk of developing dyslipidemia and osteoporosis due to estrogen deficiency, necessitating regular vitamin D supplementation and the use of cholesterol inhibitors, respectively, to prevent these conditions. Despite current treatments, alternatives are needed to address both conditions simultaneously. Ergosterol, a precursor of vitamin D, is a fungal sterol converted to brassicasterol by 7-dehydrocholesterol reductase, a cholesterol biosynthesis enzyme that converts 7-dehydrocholesterol (a precursor of vitamin D) into cholesterol.
View Article and Find Full Text PDFChin J Nat Med
January 2025
The First Clinical Academy, Guangzhou University of Chinese Medicine, Guangzhou 510405, China; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510407, China; Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou 510405, China. Electronic address:
Osteoporosis is a prevalent skeletal condition characterized by reduced bone mass and strength, leading to increased fragility. Buqi-Tongluo (BQTL) decoction, a traditional Chinese medicine (TCM) prescription, has yet to be fully evaluated for its potential in treating bone diseases such as osteoporosis. To investigate the mechanism by which BQTL decoction inhibits osteoclast differentiation in vitro and validate these findings through in vivo experiments.
View Article and Find Full Text PDFJ Ethnopharmacol
January 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China. Electronic address:
Ethnopharmacological Relevance: Emplastrum has a long history of use in the clinical practice of traditional Chinese medicine (TCM), valued for its convenient external application and pronounced therapeutic effects. Traditionally, the emplastrum was composed of numerous herbal medicines. The elucidation of their mechanisms of action are of great importance.
View Article and Find Full Text PDFJ Gene Med
January 2025
Department of Orthopedic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen City, Guangdong, China.
Purpose: Postmenopausal osteoporosis (PMO) is mainly concerned with the imbalance of bone resorption and bone formation. Icariin (ICA) plays a vital role in bone protection. This study investigated the mechanism of ICA in PMO rats.
View Article and Find Full Text PDFBiogerontology
January 2025
Department of Anatomy, College of Medicine, Tzu Chi University, No. 701, Section 3, Zhongyang Rd., Hualien, 970374, Taiwan.
Aging women experience a significant decline of ovarian hormones, particularly estrogen, following menopause, and become susceptible to cognitive and psychomotor deficits. Although the effects of estrogen depletion had been documented in the prefrontal and somatosensory cortices, its impact on somatomotor cortex, a region crucial for motor and cognitive functions, remains unclear. To explore this, we ovariectomized young adult female rats and fed subsequently with phytoestrogen-free diet and studied the effects of estrogen depletion on the somato-sensory and motor cortices.
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