Two new eunicellin-based diterpenoids, sibogins A (1) and B (2), along with one known analogue (3), and four known 9,10-secosteroids (4-7), were isolated from the gorgonian Muricella sibogae Nutting collected from the South China Sea. The structures of the new compounds were elucidated by comprehensive analysis of spectroscopic data, especially by using 2D NMR spectra. The antifouling activity on barnacle Balanus amphitrite and lethality towards brine shrimp Artemia salina of all the isolated compounds were evaluated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2014.923423 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polyoxygenated Klysimplexane- and Eunicellin-Based Diterpenoids from the Gorgonian .
Molecules
May 2021
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Three new polyoxygenated diterpenoids with a rare 4-isopropyl-1,5,8a-trimethylperhydrophenanthrane structure of the klysimplexane skeleton, briarols A‒C (1‒3), and one eunicellin-based diterpenoid, briarol D (4), were isolated from , a gorgonian inhabiting Taiwanese waters. The chemical structures of these compounds were determined by employing extensive analyses of NMR and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. Metabolites 1‒3 were found to possess the rarely found skeleton of the diterpenoid klysimplexin T.
View Article and Find Full Text PDFTerpenoids from the South China Sea soft coral .
Nat Prod Res
July 2021
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
A rare sinulariane-type norcembranoid sinulariadiolide B () with a unique cyano group, and a eunicellin-based diterpenoid multifloralin (), along with two known related analogues, sinulariadiolide () and sclerophytin E (), were isolated from the extract of the South China Sea soft coral . Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison with previously reported data. Compounds and showed potent antifouling activity against barnacle .
View Article and Find Full Text PDFFurther new eunicellin-based diterpenoids from the Guangxi Weizhou soft coral Cladiella krempfi.
Fitoterapia
November 2018
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:
Three new polyoxygenated diterpenes (1, 3 and 4) of eunicellin-type, namely, 8-n-butyryl-litophynol A, 6-keto-litophynol B and 6-epi-litophynol B, respectively, together with two related known ones (2 and 5), were isolated from the soft coral Cladiella krempfi collected off the Weizhou island, Guangxi Zhuang Autonomous Region, China. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical correlation. In bioassay, all the new compounds displayed moderate anti-inflammatory effects.
View Article and Find Full Text PDFThe marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR.
Biochem Pharmacol
February 2017
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, United States. Electronic address:
Epidermal growth factor receptor (EGFR) is a key player in proliferation and metastasis of various cancers. Discovery of novel EGFR inhibitors is still an urgent clinical oncology unmet need. Pachycladins are eunicellin-based diterpenoids isolated from the soft coral Cladiella pachycladous species.
View Article and Find Full Text PDFEunicellin-Based Diterpenoids, Hirsutalins S-V, from the Formosan Soft Coral Cladiella hirsuta.
Mar Drugs
April 2015
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!