AI Article Synopsis
- The application of a durable coating to mammalian cells, such as HeLa cells, has potential benefits in areas like cell-based sensors and regenerative medicine.
- The technique used involves a bioinspired method of silicification that enhances the cells' resistance to harmful substances while managing cell division.
- This innovative approach was successfully extended to other cell types, including NIH 3T3 fibroblasts and Jurkat cells, showcasing its versatility in cell biology research.
Article Abstract
The cytoprotective coating of physicochemically labile mammalian cells with a durable material has potential applications in cell-based sensors, cell therapy, and regenerative medicine, as well as providing a platform for fundamental single-cell studies in cell biology. In this work, HeLa cells in suspension were individually coated with silica in a cytocompatible fashion through bioinspired silicification. The silica coating greatly enhanced the resistance of the HeLa cells to enzymatic attack by trypsin and the toxic compound poly(allylamine hydrochloride), while suppressing cell division in a controlled fashion. This bioinspired cytocompatible strategy for single-cell coating was also applied to NIH 3T3 fibroblasts and Jurkat cells.
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| http://dx.doi.org/10.1002/anie.201402280 | DOI Listing |
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