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New and established treatment options for mycosis fungoides and Sézary syndrome - an update. | LitMetric

New and established treatment options for mycosis fungoides and Sézary syndrome - an update.

J Dtsch Dermatol Ges

Department of Dermatology, Fachklinik Hornheide, Münster.

Published: July 2014

AI Article Synopsis

  • * Accurate staging using various criteria is essential for determining the best treatment approach, as true cures are rare.
  • * Treatment goals focus on healing skin lesions, reducing relapse rates, preventing disease progression, and ensuring quality of life, with skin-directed therapies used initially and systemic treatments introduced in later stages.

Article Abstract

At the time of diagnosis primary cutaneous lymphomas are limited to the skin. T-cell lymphomas represent at least two thirds of all primary cutaneous lymphomas with mycosis fungoides and Sézary syndrome being the most frequent entities. A precise staging based on clinical, histological, immunohistological and molecular biological criteria is crucial for selecting the appropriate therapy. Since curative treatment is only possible in exceptional cases, the aim of any therapy is to achieve healing of the skin lesions, minimizing relapses, preventing progression and maintaining the quality of life. While in early disease stages skin-directed therapy is being used, in later stages systemic treatments become more important. This work aims to provide an overview of established and new therapies for the treatment of mycosis fungoides and Sézary syndrome.

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Source
http://dx.doi.org/10.1111/ddg.12376DOI Listing

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