AI Article Synopsis
- Intracellular pH regulation is crucial for proper cell function, particularly in sperm cells.
- Unique ion transporters and enzymes that are essential for sperm function depend on or are linked to intracellular pH levels.
- The review discusses the main components involved in pH regulation and their roles in key sperm functions like motility, maturation, and the acrosome reaction.
Article Abstract
Intracellular pH (pHi) regulation is essential for cell function. Notably, several unique sperm ion transporters and enzymes whose elimination causes infertility are either pHi dependent or somehow related to pHi regulation. Amongst them are: CatSper, a Ca(2+) channel; Slo3, a K(+) channel; the sperm-specific Na(+)/H(+) exchanger and the soluble adenylyl cyclase. It is thus clear that pHi regulation is of the utmost importance for sperm physiology. This review briefly summarizes the key components involved in pHi regulation, their characteristics and participation in fundamental sperm functions such as motility, maturation and the acrosome reaction.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146485 | PMC |
| http://dx.doi.org/10.1016/j.bbrc.2014.05.100 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!