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Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis.
Development
November 2024
Azrieli Research Center of CHU Sainte Justine, University of Montreal, Montreal H3T 1C5, QC, Canada.
Congenital scoliosis (CS) is a type of vertebral malformation for which the etiology remains elusive. The notochord is pivotal for vertebrae development, but its role in CS is still understudied. Here, we generated a zebrafish knockout of ptk7a, a planar cell polarity (PCP) gene that is essential for convergence and extension (C&E) of the notochord, and detected congenital scoliosis-like vertebral malformations (CVMs).
View Article and Find Full Text PDFImplementing a Halo Gravity Traction Program: A Multidisciplinary Endeavor.
Orthop Nurs
July 2024
Anne Stuedemann, MSN, RN, CPNP, Orthopaedic Surgery, Children's Mercy Kansas City, Kansas City, MO.
Halo gravity traction (HGT) is a preoperative modality for children with severe spinal deformity used to optimize spine flexibility and balance while decreasing the likelihood of neurologic injury. HGT is a dependable solution for these challenging spinal deformities. Aligning treatment guidelines and providing resources, education, and training for staff are key components for a successful HGT program.
View Article and Find Full Text PDFNavigation-guided endoscopic lumbar decompression on foramen and lateral recess in advanced scoliosis.
Neurosurg Focus Video
April 2024
Spine Center, Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
An 84-year-old woman presented with left leg radiating pain for 18 months and a numeric rating scale score of 8. From examination, motoric on left knee extension was grade 4, with dysesthesia and numbness along the left anterolateral thigh. Imaging showed left L3-4 foraminal and lateral recess stenosis with severe-degree scoliosis.
View Article and Find Full Text PDFTissue response following implantation with the posterior dynamic distraction device (PDDD) in adolescent idiopathic scoliosis (AIS).
Eur Spine J
June 2024
AnaPath Services GmbH, Liestal, Switzerland.
Purpose: The PDDD is a ratchet-based, unidirectional expandable rod to treat adolescent idiopathic scoliosis (AIS), primarily by correcting scoliotic deformity without full spinal fusion. We hypothesized that the device will be fully tolerated by the host and, if aseptic screw loosening occurs, it will be unrelated to wear particle formation.
Methods: This study comprised tissue samples from seven patients from a prospective study (NCT04296903) to assess the PDDD's safety and benefits, reoperated due to complications.
Pelvic Fixation Technique Using the Ilio-Sacral Screw for 173 Neuromuscular Scoliosis Patients.
Children (Basel)
February 2024
Pediatric Orthopedic Surgery Department, Necker Hospital, APHP, University of Paris-Cité, 75015 Paris, France.
Pelvic fixation remains one of the main challenging issues in non-ambulatory neuromuscular scoliosis (NMS) patients, between clinical effectiveness and a high complication rate. The objective of this multicenter and retrospective study was to evaluate the outcomes of a technique that was applied to treat 173 NMS patients. The technique is not well-known but promising; it uses the ilio-sacral screw, combined with either the posterior spinal fusion or fusionless bipolar technique, with a minimum follow-up of two years.
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