AI Article Synopsis
- Membranous nephropathy is common in adults but rare in children and was identified as the cause of nephrotic syndrome in a 16-year-old boy.* -
- The boy's condition improved after the surgical removal of a tumor called angiomatoid fibrous histiocytoma, which had not previously been linked to membranous nephropathy.* -
- This case points out the importance of considering underlying conditions like tumors in pediatric patients with secondary causes of membranous nephropathy, suggesting that urinalysis could be beneficial in such diagnoses.*
Article Abstract
Background: Though membranous nephropathy is a much more common cause of nephrotic syndrome in the adult population, it accounts for only a small fraction of cases in pediatrics.
Case-diagnosis/treatment: We report a case of a 16-year-old boy with nephrotic syndrome due to membranous nephropathy in the setting of a rare tumor, angiomatoid fibrous histiocytoma. This patient's nephrotic-range proteinuria completely resolved following resection of this tumor. Angiomatoid fibrous histiocytoma, while known to cause other paraneoplastic syndromes such as anemia, has never been reported to cause membranous nephropathy.
Conclusions: This case highlights a novel and treatable secondary cause of membranous nephropathy. Because secondary causes are more common in children than in adults, a high index of suspicion for other underlying pathology including malignancy should be considered. It also suggests that urinalysis may be a helpful screening tool in cases of angiomatoid fibrous histiocytoma.
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| http://dx.doi.org/10.1007/s00467-014-2852-1 | DOI Listing |
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