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Is There a Relationship Between Prenatal Dexamethasone and Postnatal Fructose Overexposure and Testicular Development, Function, and Oxidative Stress Parameters in Rats?
Int J Mol Sci
December 2024
Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia.
Prenatal glucocorticoid overexposure alters the developmental program of fetal reproductive organs and results in numerous changes that can lead to various disorders later in life. Moderate fructose consumption during childhood and adolescence may impair the development and function of reproductive organs. The aim of this study was to investigate the effects of prenatal dexamethasone (Dx) exposure in combination with postnatal fructose overconsumption on testicular development and function in fetal and adult male rat offspring.
View Article and Find Full Text PDFTeratoma Development in 129.MOLF-Chr19 Mice Elicits Two Waves of Immune Cell Infiltration.
Int J Mol Sci
November 2024
Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany.
Teratomas are a highly differentiated type of testicular germ cell tumors (TGCTs), the most common type of solid cancer in young men. Prominent inflammatory infiltrates are a hallmark of TGCTs, although their compositions and dynamics in teratomas remain elusive. Here, we reached out to characterize the infiltrating immune cells and their activation and polarization state by using high-throughput gene expression analysis of 129.
View Article and Find Full Text PDFSystemic alpha-1 adrenergic receptor inhibition reduces sperm damage in adult and aging spontaneously hypertensive rats.
Sci Rep
November 2024
Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 3o Floor, Room 319, Butanta, SP, 05508000, Brazil.
Article Synopsis
- * In spontaneously hypertensive rats (SHRs), researchers found lower sperm concentration, motility, and higher acrosome damage, with SHRs showing elevated blood pressure across different ages.
- * Treatment with prazosin, which blocks α1-adrenergic receptors, improved sperm concentration and motility in hypertensive rats, but did not help with acrosome damage, highlighting the impact of hypertension on sperm quality.
Cystic dysplasia of the rete testis in adulthood: a case report and review of the literature.
Ann Med Surg (Lond)
October 2024
Division of Urology, Department of Surgery, American University of Beirut Medical Center.
Background: Rete testis dysplasia is a cystic anomaly arising from the rete testis presenting normally in the pediatric population. These cases usually regress spontaneously without the need for surgical intervention. There are rare, reported cases of rete testis dysplasia in adulthood, which have been managed surgically.
View Article and Find Full Text PDFMediastinal Tumor in a Boy With GnRH-Independent Precocious Puberty and Fluctuating β-HCG Levels.
JCEM Case Rep
October 2024
The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva 4920235, Israel.
Gonadotropin-releasing hormone (GnRH(-independent premature puberty in boys, characterized by elevated β-human chorionic gonadotropin (β-hCG) levels, can indicate a secreting germ cell tumor (GCT). These tumors are rare but more common in individuals with Klinefelter syndrome (KS). We present a case of a 7.
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