AI Article Synopsis
- The differentiation of preadipocytes is essential for expanding adipose tissue, involving various regulatory factors, including Cathepsin B (CTSB).
- This study showed that CTSB enhances lipid accumulation and the expression of adipogenic genes in porcine primary preadipocytes by degrading fibronectin (Fn), a critical component of the extracellular matrix.
- Additionally, CTSB counteracts the anti-adipogenic effects of Lithium chloride (LiCl), implicating its role in influencing the Wnt/β-catenin signaling pathway, as Fn is a target of this pathway, supporting the idea that CTSB promotes preadipocyte differentiation.
Article Abstract
The process of preadipocytes differentiation plays a vital role in adipose tissue expansion and many factors are involved in this event. Cathepsin B (CTSB), secreted from lysosome, has been reported in regulating a variety of physiological processes. In this study, we demonstrated CTSB promotes lipid accumulation and adipogenic genes expression in porcine primary preadipocytes by degrading fibronectin (Fn), a key component of extracellular matrix. Lithium chloride (LiCl) is an activator of Wnt/β-catenin signaling through stabilizing β-catenin. We found that CTSB can relieve the anti-adipogenic effects of LiCl, indicating that CTSB could impact Wnt/β-catenin signaling pathway. Interestingly, Fn is an important target gene of Wnt/β-catenin. So we considered that CTSB promote preadipocytes differentiation by suppressing these two pathways.
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| http://dx.doi.org/10.1007/s11010-014-2111-6 | DOI Listing |
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