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http://dx.doi.org/10.1016/j.pedneo.2014.02.003DOI Listing

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Article Synopsis
  • - The study investigates how cerebral blood flow (CBF) varies in different brain regions under severe hypotension caused by tachyarrhythmia in anesthetized rats.
  • - Researchers found that during moderate hypotension, CBF was relatively preserved in most brain areas except the motor cortex (MC), while severe hypotension caused a selective reduction in blood flow to specific regions including the MC, thalamus, and dlPAG.
  • - The findings suggest that CBF is not uniformly affected by hypotension, and understanding this variability could improve treatment strategies for conditions like syncope and cerebral ischemia in patients with arrhythmias.
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Sudden Unexpected Death in Epilepsy: Respiratory vs. Cardiac Contributions.

Cardiovasc Res

August 2024

Graduate Program in Neuroscience, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065.

Article Synopsis
  • Sudden Unexpected Death in Epilepsy (SUDEP) is a major concern for people with epilepsy, primarily linked to recurrent convulsive seizures.
  • Current research suggests that respiratory dysfunction is a key factor leading to SUDEP, rather than heart rhythm problems.
  • Continued studies aim to uncover predictive markers for SUDEP and develop targeted treatments to improve the lives and longevity of individuals with epilepsy.
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Background: The different vulnerabilities of heart and brain to hypotension and hypoxia have been discussed. Hemorrhagic or cardiogenic hypotension appears to cause greater cerebral lesions than drug-induced hypotension. The present model was established to evaluate myocardial blood flow (MBF) and function of the heart and cerebral blood flow (CBF) during tachyarrhythmias and to characterize the capacity of blood flow regulation in the heart and brain during tachycardia-induced borderline hypotension.

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