Effects of neonatal capsaicin treatment on thiamine monophosphatase (TMPase) activity in the substantia gelatinosa of the rat spinal cord.

The present study investigated changes in gelatinosal TMPase activity following capsaicin treatment. The gelatinosal TMPase activity was positive around postnatal day 3, and the activity disappeared when newborn rats were treated with capsaicin on postnatal days 2 or 3. The absence of TMPase activity was still observed four months after treatment. The possibility that TMPase is associated with nociception has to be considered.