The developmental patterns of three ganglioside glycosyltransferases were determined in the embryonic rat cerebral hemispheres from day 14 of gestation until birth. Considering the values of day 14 of gestation as 100%, the activity per μg of DNA at birth of the CMP-NeuAc:GM3 sialosyltransferase decreased to 40%, that of UDP-GalNAc:GM3 N-acetylgalactosaminyltransferase increased to 230% and that of UDP-Gal:GM2 galactosyltransferase showed minor variations. The changes in the activities of these enzymes correlated with the changes occurring in this embryonic period in the complexity of the oligosaccharide chain of gangliosides which result in a relative increase of gangliosides having the gangliotetraosyl backbone.
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