AI Article Synopsis
- This study looks at something called patient-prosthesis mismatch (PPM) which is when a heart valve doesn't fit the patient well enough.
- The researchers measured something called mean platelet volume (MPV) in patients who had a heart valve replaced to see if it could show how active their platelets were.
- They found that patients with PPM had higher MPV levels compared to those without PPM and to healthy people, suggesting their platelets were more active.
Article Abstract
Purpose: Patient-prosthesis mismatch (PPM) is defined when the ratio of the effective orifice area of the normally functioning prosthetic valve to the body surface area of the patient is <0.85 cm(2)/m(2). The aim of this study was to assess the measurements of the mean platelet volume (MPV) as an indicator of platelet activation in patients with PPM.
Methods: A total of 109 patients with isolated aortic valve replacement (AVR) procedures with a mechanical prosthesis and a control group from a normal population of 102 people compatible in terms of age and sex were chosen for the study. The AVR group was subdivided into a PPM group (n = 41) and non-PPM group (n = 68). All patients and control participants underwent echocardiographic examinations, with simultaneous measurements of the serum MPV values.
Results: The MPV measurements were significantly higher in the patients with AVR compared to the control group (8.97 ± 0.93 vs. 8.26 ± 0.14, p < 0.001). Higher results were also obtained in the patients with PPM compared to the non-PPM group (9.36 ± 0.61 vs. 8.73 ± 1.01, p < 0.001). The platelet counts were found to be similar in both groups (p > 0.05).
Conclusions: We have herein shown that the PPM patients had a significantly higher MPV compared to the patients with AVR without PPM and healthy subjects.
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| http://dx.doi.org/10.1007/s00595-014-0933-1 | DOI Listing |
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