[Intervention effect of probiotic bifidobacterium on type 2 diabetes mellitus rats].

Objective: To observe the influences of bifidobacterium on glucose and lipid metabolism and intestinal flora in type 2 diabetes mellitus rats.

Methods: Rats were randomly divided into 4 groups, the blank control group was fed with basic forage, the other 3 groups were fed with high fat diet. Meanwhile the high-dose and low-dose groups were gavage administrated with 12 and 4 ml/(kg x d) probiotic bifidobacterium for 6 weeks, then, injected with low dose of streptozotocin (20 mg/kg). All rats were sacrificed 2 weeks later, blood and feces samples were collected to analyse.

Results: Compared with rats of type 2 diabetes model, glucose concentrations and serum concentrations of FFA, TG, LDL-C of 2 experimental groups were significantly lower, serum concentrations of HDL-C were higher, insulin sensitivity index was higher, content of bifidobacterium was higher, but there were no significant differences in other 5 bacteria.

Conclusion: The probiotic bifidobacterium could significantly ameliorate the disorder of glucose and lipid metabolism, increase the amount of bifidobacterium of type 2 diabetes rats.