Defining the outcome of patients with delayed diagnosis of differentiated thyroid cancer.

Laryngoscope

Department of Otolaryngology , Rambam Medical Center, Rappaport School of Medicine, the Technion, Israel Institute of Technology, Haifa.

Published: December 2014

AI Article Synopsis

  • * Researchers reviewed medical records of 47 patients, finding that most underwent total thyroidectomy, with a median time to surgery of 52 months and a follow-up period averaging 96 months.
  • * Results indicated a 5-year disease-free survival rate of 96%, showing that patients who had delayed treatment had outcomes comparable to those who received immediate surgery.

Article Abstract

Objectives/hypothesis: In the present study we sought to define the outcome of patients with delay in diagnosis and treatment (>1 year) of well-differentiated thyroid carcinoma (WDTC) due to initial benign cytology (IBC).

Study Design: Retrospective medical record review and analysis of survival outcomes.

Methods: The records of 47 patients with delayed diagnosis of thyroid cancer were reviewed. In 38, surgery was performed for growing nodules and in nine due to malignant cytology during follow-up. Median time to delayed surgery was 52 months (range, 13-205 months). Multivariate analysis was performed to assess variables associated with outcome.

Results: Most patients (32/47) underwent total thyroidectomy, whereas 15/47 had hemithyroidectomy. With a median follow-up of 96 months (range, 12-184 months), the 5-year disease-free survival of these patients was 96%. Multivariate analysis showed that the outcome of these patients was not statistically different than that of patients (n = 162) who underwent immediate surgery for similar disease.

Conclusions: We show that patients with delayed diagnosis and treatment for WDTC due to IBC have excellent outcome.

Level Of Evidence: 4.

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Source
http://dx.doi.org/10.1002/lary.24744DOI Listing

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