Renal oncocytosis is a very rare cause of multiple renal masses. Imaging features of renal oncocytosis and combined tumors have rarely been reported. Here, we describe a case of unilateral left renal oncocytosis and a combined hybrid tumor between chromophobe renal cell carcinoma and oncocytoma, which were depicted on CT and MR imaging as multiple enhancing solid masses with one dominant mass. Additionally, we reviewed the literature.
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http://dx.doi.org/10.1007/s11604-014-0334-9 | DOI Listing |
Am J Surg Pathol
September 2024
Department of Pathology, Johns Hopkins Hospital.
Eur J Med Res
January 2024
Department of Endocrinology and Metabolism, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Background: N-Nitrosomorpholine (NMO) is one of the most common N-nitroso compounds. An oncocytic transformation has been demonstrated in renal tubules of NMO-treated rats. In our study, we aimed to investigate the potential transformation of oncocytic cells in 6 endocrine organs, i.
View Article and Find Full Text PDFAm J Surg Pathol
February 2024
Departments of Pathology.
Birt-Hogg-Dubé (BHD) syndrome is associated with an increased risk of multifocal renal tumors, including hybrid oncocytic tumor (HOT) and chromophobe renal cell carcinoma (chRCC). HOT exhibits heterogenous histologic features overlapping with chRCC and benign renal oncocytoma, posing challenges in diagnosis of HOT and renal tumor entities resembling HOT. In this study, we performed integrative analysis of bulk and single-cell RNA sequencing data from renal tumors and normal kidney tissues, and nominated candidate biomarkers of HOT, L1CAM, and LINC01187 , which are also lineage-specific markers labeling the principal cell and intercalated cell lineages of the distal nephron, respectively.
View Article and Find Full Text PDFClin Nucl Med
September 2023
Urology, Changhai Hospital, Naval Medical University, Shanghai, China.
Renal oncocytosis is a very rare oncologically indolent form of renal neoplasia characterized by diffuse involvement of renal parenchyma by numerous oncocytic nodules. We describe contrast-enhanced CT and 99m Tc-MIBI SPECT/CT findings in a patient with renal oncocytosis presenting with metachronous bilateral renal tumors. Contrast-enhanced CT showed numerous tumors ranging from several millimeters up to 3.
View Article and Find Full Text PDFZhonghua Bing Li Xue Za Zhi
August 2022
Department of Pathology, Bishan Hospital of Chongqing Medical University, Chongqing 402760, China.
To explore clinicopathological features of low-grade oncocytic tumor (LOT) of the kidney and to analyze its relationship to hybrid oncocytic/chromophobe tumor (HOCT) of the kidney, renal oncocytoma (RO), and chromophobe renal cell carcinoma (chRCC). Seven LOTs were identified from the pathologic archives of two hospitals, including Xiangya Hospital (5 cases) and the Second Xiangya Hospital (2 cases) of Central South University between 2012 and 2019. Clinical data of the LOTs were collected.
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