AI Article Synopsis
- The study aimed to analyze the chemical components found in the stems of the plant Gymnema sylvestre using various chromatographic techniques.
- Seven distinct compounds were isolated and identified, including several known substances and a new compound, which is a triterpenoid saponin.
- The research also assessed the potential effects of compounds 1, 5-7 on the non-enzymatic glycation of proteins, finding that they have weak inhibition activities.
Article Abstract
Aim: To study the chemical constituents of stems of Gymnema sylvestre (Retz.) Schult.
Methods: Chromatographic techniques using silica gel, C18 reversed phase silica gel, and prep-HPLC were used. The structures were elucidated on the basis of MS and spectroscopic analysis (1D and 2D NMR), as well as chemical methods.
Results: Seven compounds were isolated and their structures were elucidated as conduritol A (1), stigmasterol (2), lupeol (3), stigmasterol-3-O-β-D-glucoside (4), the sodium salt of 22α-hydroxy-longispinogenin-3-O-β-D-glucopyranosyl-(1→3)-β-D-glu-curono-pyranosyl-28-O-α-L-rhamnopyranoside (5), oleanolic acid-3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (6), and the sodium salt of 22α-hydroxy-longispinogenin 3-O-β-D-glucuronopyranosyl-28-O-α-L-rhamnopyranoside (7). The inhibition activities of compounds 1, 5-7 on non-enzymatic glycation of protein in vitro were evaluated.
Conclusion: Compound 7 is a new triterpenoid saponin. It was shown that compounds 1, 5-7 have weak inhibition activities for non-enzymatic glycation of protein in vitro.
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| http://dx.doi.org/10.1016/S1875-5364(14)60059-5 | DOI Listing |
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