Introduction: Sleepiness in students has an impact on their learning, focus and memory. Sleepiness is caused by multiple factors. Therefore, our objective was to estimate the frequency of sleepiness in Peruvian students and assess its relation to lifestyle and sleep habits.
Methods: Cross-sectional study conducted on first through fifth year secondary students. The Spanish version of the pediatric daytime sleepiness scale (0 to 32 points) was administered and sleep and demographic characteristics and harmful habits, among others were investigated. Excessive sleepiness was considered as a score higher than 20 points, and its association was assessed using raw and adjusted odds ratios.
Results: The study included 586 students; the average score in the pediatric daytime sleepiness scale was 13.0 ± 5.5; 11.9% of students had excessive sleepiness. Smoking was associated with excessive sleepiness, with an adjusted OR of 6.9 (95% CI: 2.9-17.0); alcohol consumption showed an OR of 4 (95% CI: 1.5-10.5), and practicing sports showed an OR of 0.5 (95% CI: 0.3-0.9). Likewise, having a bad sleep quality (OR: 5.4; 95% CI: 3.1-9.5) and taking more than 60 minutes to fall asleep (OR: 2.5; 95% CI: 1.16.0) were associated with a higher probability of having sleepiness.
Conclusion: Sleepiness was observed in 12% of the studied population, and was found to be lower than the rates described in studies with different populations. Excessive sleepiness is associated with smoking and frequent alcohol consumption, a lower level of sports practice, and bad sleep habits.
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http://dx.doi.org/10.5546/aap.2014.eng.239 | DOI Listing |
Mov Disord Clin Pract
January 2025
Parkinson Disease and Movement Disorders Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Background: Dystonia may respond to VMAT2 inhibition.
Objectives: Providing pilot data on the safety, tolerability, and efficacy of deutetrabenazine in non dopa-responsive dystonia.
Methods: Deutetrabenazine was titrated by adults with isolated dystonia.
J Neurol
January 2025
Department of Neurology, LMU University Hospital, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.
Background And Objective: Non-motor symptoms frequently develop throughout the disease course of Parkinson's disease (PD), and pose affected individuals at risk of complications, more rapid disease progression and poorer quality of life. Addressing such symptom burden, the 2023 revised "Parkinson's disease" guideline of the German Society of Neurology aimed at providing evidence-based recommendations for managing PD non-motor symptoms, including autonomic failure, pain and sleep disturbances.
Methods: Key PICO (Patient, Intervention, Comparison, Outcome) questions were formulated by the steering committee and refined by the assigned authors.
Alzheimers Dement
December 2024
Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Background: Sleep dysfunction is commonly seen in Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP), potentially worsening these conditions. Investigating early neuropathological changes in human sleep-promoting neurons, which often precede cognitive decline, is crucial for understanding the basis for sleep dysfunction as possible treatments yet remain underexplored. We used postmortem brains of AD and PSP patients to quantify neuronal numbers and tau burden in the intermediate nucleus of the hypothalamus (IntN), VLPO analog, known for its role in sleep maintenance.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Physiopathology in Aging Laboratory (LIM-22), University of São Paulo Medical School, São Paulo, São Paulo, Brazil.
Background: Excessive daytime sleepiness is a common and early symptom of Alzheimer's disease (AD). The subcortical wake-promoting neurons in the lateral hypothalamic area, tuberomammillary nucleus (TMN), and locus coeruleus synchronize to maintain wakefulness/arousal. Although significant neuronal decline occurs in wake-promoting regions, the TMN histaminergic neurons remain relatively more intact than orexinergic and nor-adrenergic neurons.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University School of Medicine, Saint Louis, MO, USA.
Sleep disturbances, such as insomnia, are associated with Alzheimer's disease pathology and future risk of cognitive impairment. This raises the exciting possibility of repurposing existing drugs to prevent or delay Alzheimer's disease since there are multiple drug approved by the Food and Drug Administration for the treatment of insomnia. Dual orexin receptor antagonists (DORAs) are one such class of medications.
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