This article explores the use of family sculpting as an educative tool to achieve a better I-thou awareness of the patient's support needs from a family and social system approach. Ensuring we provide appropriate and effective opportunities for nurses to develop compassion when caring for patients facing ill health is a complex challenge that faces nurse education at all levels. The piece explores a sculpting exercise developed in nurse education which engages students' awareness of the complicated nature of peoples' social networks and through attitudinal learning, helps nurses to provide compassionate care that integrates family support.
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http://dx.doi.org/10.1016/j.nedt.2014.04.008 | DOI Listing |
Mol Biol Cell
January 2025
Department of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
Collective cell migration is critical for morphogenesis, homeostasis, and wound healing. Migrating mesenchymal cells form tissues that shape the body's organs. We developed a powerful model, exploring how nascent myotubes migrate onto the testis during pupal development, forming the muscles ensheathing it and creating its characteristic spiral shape.
View Article and Find Full Text PDFMethods Mol Biol
December 2024
Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Adenosin triphosphate (ATP)-dependent nucleosome remodeling factors sculpt the nucleosomal landscape of eukaryotic chromatin. They deposit, evict, or reposition nucleosomes along DNA in a process termed nucleosome sliding. Remodeling has traditionally been analyzed using mononucleosomes as a model substrate.
View Article and Find Full Text PDFAcc Chem Res
December 2024
Key Laboratory of Biomedical Polymers, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
ConspectusThe past decades have witnessed the proliferation of porous materials offering high surface areas and the revolution in gas storage and separation, where metal-organic frameworks (MOFs) stand out as an important family. Alongside the pursuit of higher surface area, the increase in the size of guests, such as nanoparticles and biomolecules, has also led to the demand for larger space defined by the pores and cages within the MOF structure, from the conventional micropore regime (<2 nm) toward the mesopore regime (2-50 nm). Among the essential elements in the design of MOFs, molecular building blocks, their coordination and spatial arrangement, the chemistry for molecular design, and coordination bonds have become relatively mature, offering precise control of the shape and environment of the molecularly defined 3D cages; however, the correlation between the geometrical parameters and the size of polyhedrons describing the cages, concerning the spatial arrangement of building blocks, is much less explored.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
Massive numbers of modified bases in mRNAs sculpt the epitranscriptome and play vital roles in RNA metabolism. The only known acetylated RNA modification, N-4-acetylcytidine (acC), is highly conserved across cell types and among species. Although the GCN5-related acetyltransferase 10 (NAT10) functions as an acC writer, the mechanism underlying the acetylation process is largely unknown.
View Article and Find Full Text PDFCurr Opin Cell Biol
October 2023
Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.
The Arf family GTPases are regulators of eukaryotic cellular organization, functioning in the secretory and endocytic pathways, in cilia and flagella, in cytoskeleton dynamics, and in lipid metabolism. We describe the evolution of this protein family and its well-studied regulators. The last eukaryotic common ancestor had fifteen members, and the current complement of Arf GTPases has been sculpted by gene loss and gene duplications since that point.
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