Antiarrhythmic effects of a series of N-substituted derivatives of 2-amino-2-methylpropanol were studied using isolated papillary muscle preparation of guinea-pig heart in order to evaluate the chemical structure--biological activity relationship. All tested drugs were found to belong to the 1st group of antiarrhythmic agents characterized by the depression of normal electrophysiological properties of the heart muscle cell. The most active compounds were phenylethyl and p-bromophenylethyl derivatives, the effects of which were comparable with those of quinidine.
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