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Hilbert transform analysis of the mouse scotopic electroretinogram reveals two distinct bursts of oscillatory potentials with progressively dimmer flashes.
Doc Ophthalmol
January 2025
Department of Ophthalmology and Visual Sciences, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, 1001 Décarie Boulevard, Glen Site, Block E, Office #EM03238, Montréal, QC, H4A 3J1, Canada.
Purpose: Study the scotopic oscillatory potentials (OPs) in mice over a wide range of flash luminance levels using the Hilbert transform (HT) to extract new features of the high frequency components of the electroretinogram (ERG).
Methods: Scotopic ERGs [Intensity: - 6.3 to 0.
Doxorubicin prodrug for γ-glutamyl transpeptidase imaging and on-demand cancer therapy.
Biosens Bioelectron
March 2025
College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, PR China; Laoshan Laboratory, Qingdao, 266237, PR China. Electronic address:
The γ-glutamyl transpeptidase (γ-GGT) is an important tumor marker, which has been reported to be firmly associated with the developmental stage of liver cancer. Therefore, it makes sense to image and monitor γ-GGT level and design γ-GGT-responsive prodrug for integrated diagnosis and treatment of liver cancer. Herein, we prepare a doxorubicin (Dox) prodrug for imaging γ-GGT and on-demand treating liver cancer.
View Article and Find Full Text PDFPlacental inflammatory response and association with the severity of neonatal hypoxic ischemic encephalopathy.
Early Hum Dev
December 2024
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:
Article Synopsis
- This study investigates the link between placental lesions and neonatal hypoxic-ischemic encephalopathy (HIE), focusing on mild versus moderate to severe cases of HIE.
- Researchers analyzed data from 394 neonates diagnosed with HIE, finding that inflammatory responses in placentas were more common in those with moderate to severe HIE compared to mild cases.
- The results indicate that increased severity of placental inflammatory responses correlates with higher severity levels of HIE, emphasizing the potential impact of placental health on neonatal outcomes.
Potassium channels mediate nitric oxide-induced vasorelaxation in arteries supplying colon cancer.
Prostaglandins Other Lipid Mediat
January 2025
Department of Biology, College of Science, University of Zakho, Duhok, Kurdistan Region, Iraq; Department of Biology, College of Science, University of Nawroz, Duhok, Kurdistan Region, Iraq.
Introduction: Aberrant vascular function and cancer growth are closely related, with nitric oxide (NO) being a key factor in vascular tone regulation. This study provides Novel insights into the distinctive mechanisms underlying cancer-associated vascular dysfunction by investigating the involvement of potassium (K) channels in NO-mediated vasorelaxation within arteries supplying colon cancer.
Methods: Arterial segments from colon cancer patients were isolated and sectioned into rings, these rings were mounted in an organ bath filled with Krebs' solution and maintained at 37°C.
Multiferroic Tuning of Magnetic Anisotropy in MnTe Monolayer with Li/Na Adsorption.
J Phys Chem Lett
December 2024
School of Physics, State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.
Two-dimensional (2D) magnetic materials with tunable magnetic anisotropy energy (MAE) are of great scientific interest and hold immense promise for ultracompact spintronic devices with lower energy consumption and higher storage density. Here, we demonstrate a practical approach for manipulating MAE in layered MnTe through the alkali metal adsorption and ferroelectric (FE) polarization effect. Our results reveal colossal MAE values of up to -12.
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