In this study, we identified water-soluble C60 and C70 fullerene derivatives as a novel class of protein tyrosine phosphatase inhibitors. The evaluated compounds were found to inhibit CD45, PTP1B, TC-PTP, SHP2, and PTPβ with IC50 values in the low micromolar to high nanomolar range. These results demonstrate a new strategy for designing effective nanoscale protein tyrosine phosphatase inhibitors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2014.04.110 | DOI Listing |
Publication Analysis
Top Keywords
protein tyrosine
12
fullerene derivatives
8
tyrosine phosphatase
8
phosphatase inhibitors
8
derivatives class
4
class inhibitors
4
inhibitors protein
4
tyrosine phosphatases
4
phosphatases study
4
study identified
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!