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Updates on the clinical application of glass ionomer cement in restorative and preventive dentistry.
J Dent Sci
December 2024
Faculty of Dentistry, The University of Hong Kong, Hong Kong, S.A.R., China.
The World Health Organization (WHO) has added glass ionomer cement (GIC) to the WHO Model List of Essential Medicines since 2021, which represents the most efficacious, safe and cost-effective medicines for priority conditions. With the potential increase in the use of GIC, this review aims to provide an overview of the clinical application of GIC with updated evidence in restorative and preventive dentistry. GIC is a versatile dental material that has a wide range of clinical applications, particularly in restorative and preventive dentistry.
View Article and Find Full Text PDFKorth toxicity: Experimental findings and future prospects.
J Taibah Univ Med Sci
December 2024
Drug Discovery and Synthetic Chemistry Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
(Roxb.) Korth, locally known as kratom, is a traditional medicinal plant from Southeast Asia, with mitragynine as its principal alkaloid. Similar to other medicinal plants, kratom has side effects and toxicities, which have been documented in scientific studies and case reports.
View Article and Find Full Text PDFHistomorphometric Assessment of Non-Decalcified Plastic-Embedded Specimens for Evaluation of Bone Regeneration Using Bone Substitute Materials-A Systematic Review.
Materials (Basel)
December 2024
Department of Clinical Medical Sciences, Faculty of Dental Medicine, Medical University of Varna, 9002 Varna, Bulgaria.
Article Synopsis
- The implementation of bone substitute materials has led to advancements in bone regeneration strategies, with a focus on histomorphometry for assessing bone structure.
- A systematic review analyzed 118 studies from the past decade, revealing that rats are the most commonly used animal model for research, with toluidine blue being the preferred staining method.
- Key histomorphometric parameters evaluated included new bone formation and mineral apposition rate, with calcein green favored for dynamic histomorphometry, while the review also highlighted weaknesses in current research protocols.
SNOMED-CT and learning health systems for NHS dentistry - a dream needing to become reality.
Br Dent J
January 2025
Professor of Oral and Maxillofacial Surgery, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK; Bloomsbury Trust, London, UK.
There has been discussion and confusion about SNOMED-CT (systematised nomenclature of medicine clinical terminology), learning health systems (LHSs) and their relevance in dentistry. This article aims to provide an overview of SNOMED-CT, LHSs and the all-too-often omitted patient and service benefits from their use. LHSs are delivering impactful benefits to patients and services globally in medicine.
View Article and Find Full Text PDFNew Insights into the Modifications and Bioactivities of Indole-3-Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review.
Mini Rev Med Chem
January 2025
Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru 81310, Johor, Malaysia.
Indole, a ubiquitous structural motif in bioactive compounds, has played a pivotal role in drug discovery. Among indole derivatives, indole-3-carboxaldehyde (I3A) has emerged as a particularly promising scaffold for the development of therapeutic agents. This review delves into the recent advancements in the chemical modification of I3A and its derivatives, highlighting their potential applications in various therapeutic areas.
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