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Continuous manufacturing of solid lipid nanoparticles by hot melt extrusion. | LitMetric

Continuous manufacturing of solid lipid nanoparticles by hot melt extrusion.

Int J Pharm

Department of Pharmaceutics & Drug Delivery, Pii Center for Pharmaceutical Technology, School of Pharmacy, The University of Mississippi, MS 38677, USA. Electronic address:

Published: August 2014

AI Article Synopsis

Article Abstract

Solid lipid nanoparticles (SLN) can either be produced by hot homogenization of melted lipids at higher temperatures or by a cold homogenization process. This paper proposes and demonstrates the formulation of SLN for pharmaceutical applications by combining two processes: hot melt extrusion (HME) technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. This work aimed at developing continuous and scalable processes for SLN by mixing a lipid and aqueous phase containing an emulsifier in the extruder barrel at temperatures above the melting point of the lipid and further reducing the particle size of emulsion by HPH linked to HME in a sequence. The developed novel platform demonstrated better process control and size reduction compared to the conventional process of hot homogenization (batch process). Varying the process parameters enabled the production of SLN below 200 nm (for 60 mg/ml lipid solution at a flow rate of 100ml/min). Among the several process parameters investigated, the lipid concentration, residence time and screw design played major roles in influencing the size of the SLN. This new process demonstrates the potential use of hot melt extrusion technology for continuous and large-scale production of SLN.

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Source
http://dx.doi.org/10.1016/j.ijpharm.2014.05.024DOI Listing

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