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Persisting Gaps in Cytomegalovirus Prevention and Management After Solid Organ Transplantation in a Resource-Limited Setting.
Transpl Infect Dis
January 2025
Department of Infectious Diseases, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil.
Background: Cytomegalovirus (CMV) infection remains among the leading complications after solid organ transplantation (SOT). Large international surveys mainly focused on high-income countries, detected considerable variability in the management of this infection after SOT. Limited data are available from resource-limited settings.
View Article and Find Full Text PDFCongenital Cytomegalovirus Severity Definitions and Treatment Decisions around the World: A Systematic Scoping Review of the Literature.
J Clin Med
October 2024
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario, Agostino Gemelli-IRCCS, 00168 Rome, Italy.
Congenital cytomegalovirus (cCMV) is the most common cause of congenital infection and the leading cause of non-genetic sensorineural hearing loss in childhood. While treatment trials have been conducted in symptomatic children, defining asymptomatic infection can be complex. We performed a scoping review to understand how infection severity is defined and treated globally, as well as the various indications for initiating treatment.
View Article and Find Full Text PDFFecal microbiota transplantation in a patient with chronic diarrhea and primary and secondary immunodeficiency (common variable immunodeficiency and splenectomy).
Front Cell Infect Microbiol
October 2024
Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
The gut microbiota serves a crucial role in the development of host immunity. Immunocompromised patients are particularly vulnerable to dysbiosis not only by virtue of a defect in the immune system but also due to increased susceptibility to infection and multiple courses of antibiotic therapy. Fecal microbiota transplantation is by far the most effective option for restoring gastrointestinal homeostasis.
View Article and Find Full Text PDFCharacterization of Ganciclovir Dosing for the Management of Cytomegalovirus in Solid Organ Transplant Recipients Receiving Sustained Low-Efficiency Dialysis.
Ann Pharmacother
September 2024
University Health Network, Toronto, Ontario, Canada.
Background: The optimal dosing of intravenous ganciclovir in patients receiving sustained low-efficiency dialysis (SLED) remains unclear.
Objective: The primary objective is to characterize the dosing of ganciclovir for treating and preventing cytomegalovirus (CMV) in Solid Organ Transplant Recipients receiving SLED. The secondary objective is to evaluate the safety and efficacy of the dosing practices described in this study.
Management of cytomegalovirus infection after liver transplantation.
World J Transplant
September 2024
Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Türkiye.
Article Synopsis
- Cytomegalovirus (CMV) infection is a major cause of complications and death after liver transplantation, making effective prevention crucial.
- Current guidelines recommend antiviral prophylaxis and pre-emptive treatment, while CMV-IgG serology is the standard method for screening donors and recipients before transplantation.
- Ongoing studies are evaluating new antiviral treatments and immune functional tests, but a consensus on the best individual management strategies for CMV remains to be established, as high-risk patients still face a significant risk of developing the disease.
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