AI Article Synopsis
- The study aimed to investigate the neuroprotective effects of carnosine during the early stages of a stroke using rodent models.
- Researchers treated rodents with varying doses of carnosine and found that a 500 mg dose significantly reduced brain damage and increased antioxidant levels in the brain and blood.
- The findings suggest that carnosine helps protect neuronal cells by reducing oxidative stress, making it a potential therapeutic option for early ischemic stroke treatments.
Article Abstract
Objective: This study was conducted to elucidate neuroprotective effect of carnosine in early stage of stroke.
Methods: Early stage of rodent stroke model and neuroblastoma chemical hypoxia model was established by middle cerebral artery occlusion and antimycin A. Neuroprotective effect of carnosine was investigated with 100, 250, and 500 mg of carnosine treatment. And antioxidant expression was analyzed by enzyme linked immunosorbent assay (ELISA) and western blot in brain and blood.
Results: Intraperitoneal injection of 500 mg carnosine induced significant decrease of infarct volume and expansion of penumbra (p<0.05). The expression of superoxide dismutase (SOD) showed significant increase than in saline group in blood and brain (p<0.05). In the analysis of chemical hypoxia, carnosine induced increase of neuronal cell viability and decrease of reactive oxygen species (ROS) production.
Conclusion: Carnosine has neuroprotective property which was related to antioxidant capacity in early stage of stroke. And, the oxidative stress should be considered one of major factor in early ischemic stroke.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024810 | PMC |
| http://dx.doi.org/10.3340/jkns.2014.55.3.125 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!