AI Article Synopsis
- Amplification of HCV RNA from blood revealed that 30.9% of 210 HCV-seronegative dialysis patients had occult HCV infections, despite normal testing methods.
- The study also found three additional patients who tested negative for HCV but had isolated HCV core-specific antibodies, indicating they could still be infectious.
- These discoveries suggest that current management practices in dialysis centers may need to be updated to better identify and manage hidden HCV infections.
Article Abstract
Amplification of hepatitis C virus (HCV) RNA from blood detected occult HCV infections in 30.9% of 210 HCV-seronegative dialysis patients with abnormal liver enzyme levels that had evaded standard HCV testing practices. Isolated HCV core-specific antibody detection identified three additional anti-HCV screening-negative patients lacking HCV RNA amplification in blood who were considered potentially infectious. Together, these findings may affect management of the dialysis setting.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136170 | PMC |
| http://dx.doi.org/10.1128/JCM.01339-14 | DOI Listing |
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