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[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma. | LitMetric
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[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.

David Sweeney Fay Hollins Edith Gomez Ruth Saunders R A John Challiss Christopher E Brightling

Respirology

Institute for Lung Health, Department of Infection, Immunity and Inflammation, NIHR Biomedical Unit, Glenfield Hospital, University of Leicester, Leicester, UK; Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK.

Published: July 2014

The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190647PMC
http://dx.doi.org/10.1111/resp.12318DOI Listing

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