AI Article Synopsis
- The study aimed to evaluate the occurrence of perihepatic lymph node enlargement (PLNE) in patients with chronic hepatitis B virus (HBV) infection, addressing a gap in understanding when compared to chronic hepatitis C.
- Among the 288 patients analyzed, PLNE was found in 9.4% of cases, indicating it’s less common than in chronic hepatitis C but more so than in general health checks, with certain liver enzyme levels and lower platelet counts linked to its presence.
- The results suggested that while PLNE is associated with liver fibrosis and injury, it appears to have a negative correlation with hepatocellular carcinoma (HCC) in those infected with HBV.
Article Abstract
Aim: Although perihepatic lymph node enlargement (PLNE) is frequently observed in chronic liver disease, little is known about PLNE in chronic hepatitis B virus (HBV) infection. We aimed to evaluate this issue.
Methods: We originally enrolled a consecutive 502 patients with chronic HBV infection. Among them, 288 patients without history of interferon-based or nucleoside analog treatment and hepatocellular carcinoma (HCC) were primarily analyzed.
Results: PLNE was detected in 27 of 288 (9.4%) patients, which was fewer than that in chronic hepatitis C patients but more than that in subjects undertaking a general health examination as previously reported. The presence of PLNE was significantly associated with a higher probability of having an aspartate aminotransferase (AST) platelet ratio index of more than 1.5 (11.1% vs 1.5%, P = 0.01), a higher AST level (38.0 vs 26.8 U/L, P = 0.001), a higher alanine aminotransferase level (50.1 vs 28.0 U/L, P < 0.0001), and a lower platelet count (18.6 vs 20.6 × 10(4) /μL, P = 0.048) after adjustment for sex and age. However, in our original sample (n = 502), PLNE was observed in 1.4% of the patients with HCC and/or its history whereas 9.2% of the patients without HCC, and the proportion was significantly lower in patients with HCC and/or its history (P = 0.03).
Conclusion: PLNE was associated with liver fibrosis and hepatocellular injury, but was negatively associated with HCC in chronic HBV infection.
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