Background: Intracranial pressure (ICP) monitoring has been for decades a cornerstone of traumatic brain injury (TBI) management. Nevertheless, in recent years, its usefulness has been questioned in several reports. A group of neurosurgeons and neurointensivists met to openly discuss, and provide consensus on, practical applications of ICP in severe adult TBI.
Methods: A consensus conference was held in Milan on October 5, 2013, putting together neurosurgeons and intensivists with recognized expertise in treatment of TBI. Four topics have been selected and addressed in pro-con presentations: 1) ICP indications in diffuse brain injury, 2) cerebral contusions, 3) secondary decompressive craniectomy (DC), and 4) after evacuation of intracranial traumatic hematomas. The participants were asked to elaborate on the existing published evidence (without a systematic review) and their personal clinical experience. Based on the presentations and discussions of the conference, some drafts were circulated among the attendants. After remarks and further contributions were collected, a final document was approved by the participants. The group made the following recommendations: 1) in comatose TBI patients, in case of normal computed tomography (CT) scan, there is no indication for ICP monitoring; 2) ICP monitoring is indicated in comatose TBI patients with cerebral contusions in whom the interruption of sedation to check neurological status is dangerous and when the clinical examination is not completely reliable. The probe should be positioned on the side of the larger contusion; 3) ICP monitoring is generally recommended following a secondary DC in order to assess the effectiveness of DC in terms of ICP control and guide further therapy; 4) ICP monitoring after evacuation of an acute supratentorial intracranial hematoma should be considered for salvageable patients at increased risk of intracranial hypertension with particular perioperative features.
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http://dx.doi.org/10.1007/s00701-014-2127-4 | DOI Listing |
Vet Res Commun
December 2024
Istituto Zooprofilattico Sperimentale della Sicilia, via Gino Marinuzzi 3, Palermo, 90129, Italy.
Heavy metals and metalloids are increasingly recognised as a threat to avian health, especially in species at the top of the food chain such as vultures. Griffon Vultures (Gyps fulvus) are ideal bioindicators for studying environmental contamination due to their scavenging habits and territorial behavior. In this study, we analysed the concentrations of six trace elements (Cd, Pb, Cr, Sb, Ni, and Cu) in feathers, pectoral plumage, and blood samples of Griffon Vultures from a captive environment in Sicily, Southern Italy, using an ICP-MS method.
View Article and Find Full Text PDFJ Xenobiot
November 2024
Grupo de Investigación en Toxicología Ambiental y Seguridad de los Alimentos y Medicamentos, Universidad de La Laguna, 38071 La Laguna, Canary Islands, Spain.
The increasing consumption of chia seeds is followed by a growing interest in their nutritional and toxicological characterization. To assess the characterization of the essential and PTEs of this novel food, 20 samples of conventional and organic chia seeds available on the European market were analyzed using ICP-OES. Then, the dietary exposure to these elements was assessed.
View Article and Find Full Text PDFJ Neurotrauma
December 2024
Department of Medical Sciences, Section of Neurosurgery, Uppsala University, Uppsala, Sweden.
This study compared the roles of extraparenchymal autonomic nervous system (ANS) control of cerebral blood flow (CBF) versus intraparenchymal cerebrovascular autoregulation in 487 patients with aneurysmal subarachnoid hemorrhage (SAH) and 413 patients with traumatic brain injury (TBI). Vasomotion intensity of extraparenchymal and intraparenchymal vessels were quantified as the amplitude of oscillations of arterial blood pressure (ABP) and intracranial pressure (ICP) in the very low frequency range of 0.02-0.
View Article and Find Full Text PDFEnviron Geochem Health
December 2024
Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Cocoa-growing areas in Ghana have experienced a rise in mining activities affecting cocoa cultivation and increased concentrations of potentially toxic metals in the soil, which can accumulate in cocoa beans. This study evaluated potential toxic metal contamination in cocoa beans and soils from cocoa farms in mining and non-mining areas in Ghana. We used X-ray fluorescence and an ICP-MS to determine metal concentrations, and a Zeeman mercury analyzer to determine mercury.
View Article and Find Full Text PDFInt J Integr Care
December 2024
Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Introduction: The SCUBY project aimed to provide knowledge on the scaling-up of an Integrated Care Package (ICP) for type 2 diabetes and hypertension across three distinct health systems (Cambodia, Slovenia, and Belgium). Here, we analyse the different elements of the country-specific scale-up roadmaps to identify similarities and differences, and share lessons learned.
Methods: Thematic analysis was used to derive crucial roadmap elements from key SCUBY documents (n = 20), including policy briefs, interim reports, research outputs, and consortium meeting notes.
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