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High prevalence of atrial conduction abnormalities in Lewy body disease - a marker of cardiac complications?
Geroscience
January 2025
Division of Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Increasing evidence suggests that Lewy body disease (LBD) is associated with clinically important cardiac complications, including sick sinus syndrome, atrial fibrillation and sudden cardiac death. The high prevalence of sick sinus syndrome and atrial fibrillation in LBD suggests the presence of disease-related atrial conduction disorders. To explore whether LBD is associated with atrial conduction disorders, electrocardiographic (ECG) P wave parameters were analyzed in a cohort of LBD patients (n = 74), using age-matched Alzheimer's disease (AD) patients (n = 25) as controls.
View Article and Find Full Text PDFFunctional Outcomes Following Partial Osteotomy of the Calcaneal Tuberosity for Haglund's Syndrome.
Cureus
November 2024
Orthopedics and Traumatology, Chettinad Hospital and Research Institute, Chennai, IND.
Background Haglund's syndrome, a common cause of pain in the posterior heel that consists of painful swelling of the local soft tissues and prominence of the posterosuperior calcaneal projection, presents significant challenges in treatment, particularly when conservative management fails. This study evaluates the functional outcomes following oblique partial excision of the posterosuperior portion (calcaneal tuberosity osteotomy) of the calcaneus for Haglund's syndrome. Methods A cohort of 30 patients, aged 18 years and older, with persistent heel pain unresponsive to conservative treatments, underwent partial osteotomy using a medial or lateral approach.
View Article and Find Full Text PDFComplications Following Surgical Treatment of Haglund's Syndrome With and Without Flexor Hallucis Longus Tendon Transfer.
J Am Acad Orthop Surg Glob Res Rev
December 2024
From the Department of Orthopedic Surgery, Duke University Hospital, Durham, NC.
Background: In the surgical treatment of Haglund syndrome, combining a flexor hallucis longus (FHL) tendon transfer with Achilles tendon may improve plantarflexion strength and reduce strain on the repaired Achilles tendon. However, there is limited research comparing complication rates between surgical approaches with or without concurrent FHL tendon transfer.
Methods: This was retrospective study of patients who underwent surgical management for Haglund syndrome between January 2015 and December 2023.
Outcomes of Revision surgery for surgically treated insertional Achilles tendinopathy.
Arch Orthop Trauma Surg
December 2024
Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center, Munich (MUM), University Hospital, LMU Munich, Munich, Germany.
Introduction: There is a clear roadmap for the treatment of primary insertional Achilles tendinopathy (IAT), but data on the outcome of revision surgery is missing. The current study aimed to analyze the outcome following revision surgery for surgically failed IAT.
Material And Methods: Included were patients with IAT revision surgery at a single reference center (01/2010-10/2016) and a follow-up of at least 12 months.
Prospective Screening of Cancer Syndromes in Patients with Mesenchymal Tumors.
Cancers (Basel)
November 2024
Department of Oncology-Pathology, Karolinska Institutet, 17164 Stockholm, Sweden.
Background: The etiology of most mesenchymal tumors is unknown, and knowledge about syndromes with an increased risk of tumors in bone or soft tissue is sparse.
Methods: We present a prospective germline analysis of 312 patients with tumors suspected of being sarcomas at a tertiary sarcoma center. Germline and tumor whole genome sequencing, tumor transcriptome, and methylome analyses were performed.
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