AI Article Synopsis
- The reaction of tetraarylbut-2-yne-1,4-diols with electron-rich aromatic compounds, using p-TsOH as a catalyst at room temperature, leads to the creation of substituted polycyclic aromatic indene derivatives.
- This process involves a domino reaction that forms a cationic allenylium intermediate, which can participate in competitive intramolecular cascade reactions.
- The described method efficiently synthesizes substituted indenes and inden-2-ones from aromatic ketones in just two steps.
Article Abstract
The reaction of tetraarylbut-2-yne-1,4-diols with electron-rich aromatic compounds at room temperature, under p-TsOH catalysis, affords substituted polycyclic aromatic indene derivatives through a domino reaction involving the formation of a cationic allenylium intermediate. This species can undergo a series of competitive intramolecular cascade reactions, leading to a conjugated inden-2-one. This simple method allows the efficient synthesis of substituted indenes and inden-2-ones, in two steps, from aromatic ketones.
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Article Synopsis
- The reaction of tetraarylbut-2-yne-1,4-diols with electron-rich aromatic compounds, using p-TsOH as a catalyst at room temperature, leads to the creation of substituted polycyclic aromatic indene derivatives.
- This process involves a domino reaction that forms a cationic allenylium intermediate, which can participate in competitive intramolecular cascade reactions.
- The described method efficiently synthesizes substituted indenes and inden-2-ones from aromatic ketones in just two steps.
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