AI Article Synopsis
- The synthesis of triazolyl azido alcohols involves a one-pot methodology using terminal alkyne and epichlorohydrin, followed by a click reaction with alkyne and azidation of chlorohydroxy triazoles.
- These triazolyl azido alcohols are then used to create various morpholine-fused triazoles that have potential chemotherapeutic benefits.
- The structures of the newly developed compounds were characterized using techniques like IR, NMR, MS, and elemental analysis, with four specifically analyzed through single-crystal X-ray analysis.
Article Abstract
The synthesis of triazolyl azido alcohols from terminal alkyne via oxirane ring-opening of epichlorohydrin, followed by click reaction with alkynes, and subsequent azidation of chlorohydroxy triazoles was achieved under a one-pot methodology. The developed triazolyl azido alcohols were further utilized for the synthesis of a diverse range of morpholine-fused triazoles of chemotherapeutic value. The structure of all developed compounds has been elucidated using IR, NMR, MS, and elemental analysis, where four of them have been characterized by single-crystal X-ray analysis.
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Article Synopsis
- The synthesis of triazolyl azido alcohols involves a one-pot methodology using terminal alkyne and epichlorohydrin, followed by a click reaction with alkyne and azidation of chlorohydroxy triazoles.
- These triazolyl azido alcohols are then used to create various morpholine-fused triazoles that have potential chemotherapeutic benefits.
- The structures of the newly developed compounds were characterized using techniques like IR, NMR, MS, and elemental analysis, with four specifically analyzed through single-crystal X-ray analysis.
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