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First results of direct selective laser trabeculoplasty for the treatment of glaucoma.
BMJ Open Ophthalmol
March 2025
Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Caserta, Italy.
Aim: To evaluate the efficacy and safety of direct selective laser trabeculoplasty (DSLT) on eyes with primary open-angle glaucoma (POAG) and on primary angle closure glaucoma (PACG) eyes at 1 year follow-up.
Methods: In this study, 54 patients affected by POAG (76) or PACG (28) undergoing DSLT were enrolled, for a total of 104 eyes. Before each treatment and at each follow-up visit, all subjects underwent a complete eye visit, including the collection of data regarding the number and type of topical medications prescribed for glaucoma.
Off-label drug use in palliative medicine: Delphi study for the consensus of evidence-based treatment recommendations.
Palliat Med
March 2025
Department of Palliative Medicine, LMU University Hospital, Ludwig-Maximilians-University in Munich, Munich, Germany.
Background: Off-label use of drugs is an integral part of everyday clinical practice in palliative medicine. However, it is associated with many uncertainties, that is, drug therapy safety or legal issues including cost coverage. Healthcare professionals often lack time and resources for comprehensive literature search and patient-specific risk-benefit analyses.
View Article and Find Full Text PDFDrug-Induced Gingival Enlargement: A Comparative Study on the Effect of Phenytoin, Gabapentin, and Cyclosporin on Gingival Fibroblast Cells.
Mol Biotechnol
March 2025
Department of Prosthodontics and Crown and Bridge, Yenepoya Dental College, Yenepoya Deemed to be a University, Deralakatte, Mangalore, Karnataka, 575018, India.
Drug-induced gingival enlargement (DIGE) is an abnormal overgrowth that may occur as a side effect in some patients when calcium channel blockers, immunosuppressants, or anticonvulsants are taken. The prevalence of DIGE was shown to be 70% for phenytoin (30% for other anticonvulsant medicines) and 50-80% for cyclosporine. The usage of these medications is increasing as new indications emerge.
View Article and Find Full Text PDFSpecific clinical conditions for colloids use.
Clin Nutr ESPEN
March 2025
Department of Acute Medicine, Medical University of Silesia, Zabrze, Poland.
Intravenous fluids are among the most commonly prescribed drugs. Many preparations classified by composition as crystalloids or colloids, of natural or synthetic origin, are available in clinical practice. Guidelines favor crystalloids as first-choice fluids in most clinical situations, mainly because of the lack of advantage of using colloids in reducing mortality and organ complications and generating higher treatment costs.
View Article and Find Full Text PDFRates of Postoperative Heart Failure among Type 2 Diabetics with Use of Nonsteroidal Anti-Inflammatory Drugs for Total Knee Arthroplasty.
J Arthroplasty
March 2025
Department of Orthopedic Surgery, NYU Langone Health, New York, New York. Electronic address:
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) can increase fluid retention and the risk of heart failure (HF). Type 2 diabetes mellitus (T2DM) is known to increase the risk of cardiac disease, including HF. As part of a modern multimodal pain protocol, NSAIDs are commonly used in total knee arthroplasty (TKA), but the risk of NSAID use in TKA for T2DM patients is not well understood.
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