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The functional role of oscillatory dynamics in neocortical circuits: A computational perspective.
Proc Natl Acad Sci U S A
January 2025
Ernst Strüngmann Institute, Frankfurt am Main 60528, Germany.
The dynamics of neuronal systems are characterized by hallmark features such as oscillations and synchrony. However, it has remained unclear whether these characteristics are epiphenomena or are exploited for computation. Due to the challenge of selectively interfering with oscillatory network dynamics in neuronal systems, we simulated recurrent networks of damped harmonic oscillators in which oscillatory activity is enforced in each node, a choice well supported by experimental findings.
View Article and Find Full Text PDFAdaptive functioning in children and young adults with monogenic neurodevelopmental disorders.
Dev Med Child Neurol
January 2025
Speech and Language, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Aim: To examine the adaptive behaviour profiles of children with monogenic neurodevelopmental disorders (NDDs) to determine whether syndrome-specific or transdiagnostic approaches provide a better understanding of the adaptive behavioural phenotypes of these NDDs.
Method: This cross-sectional study included parents and caregivers of 243 (48% female) individuals (age range = 1-25 years; mean = 8 years 10 months, SD = 5 years 8 months) with genetically confirmed monogenic NDDs (CDK13, DYRK1A, FOXP2, KAT6A, KANSL1, SETBP1, BRPF1, and DDX3X). Parents and caregivers completed the Vineland Adaptive Behavior Scales, Third Edition to assess communication, daily living, socialization, and motor skills.
A 3D decoupling Alzheimer's disease prediction network based on structural MRI.
Health Inf Sci Syst
December 2025
School of Mathematics and Computing, University of Southern Queensland, 487-535 West Street, Toowoomba, QLD 4350 Australia.
Purpose: This paper aims to develop a three-dimensional (3D) Alzheimer's disease (AD) prediction method, thereby bettering current predictive methods, which struggle to fully harness the potential of structural magnetic resonance imaging (sMRI) data.
Methods: Traditional convolutional neural networks encounter pressing difficulties in accurately focusing on the AD lesion structure. To address this issue, a 3D decoupling, self-attention network for AD prediction is proposed.
Memory consolidation from a reinforcement learning perspective.
Front Comput Neurosci
January 2025
Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon, Republic of Korea.
Memory consolidation refers to the process of converting temporary memories into long-lasting ones. It is widely accepted that new experiences are initially stored in the hippocampus as rapid associative memories, which then undergo a consolidation process to establish more permanent traces in other regions of the brain. Over the past two decades, studies in humans and animals have demonstrated that the hippocampus is crucial not only for memory but also for imagination and future planning, with the CA3 region playing a pivotal role in generating novel activity patterns.
View Article and Find Full Text PDFFabrication of nonplanar tapered fibers to integrate optical and electrical signals for neural interfaces in vivo.
Nat Protoc
January 2025
Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Arnesano, Italy.
Implantable multifunctional probes have transformed neuroscience research, offering access to multifaceted brain activity that was previously unattainable. Typically, simultaneous access to both optical and electrical signals requires separate probes, while their integration into a single device can result in the emergence of photogenerated electrical artifacts, affecting the quality of high-frequency neural recordings. Among the nontrivial strategies aimed at the realization of an implantable multifunctional interface, the integration of optical and electrical capabilities on a single, minimally invasive, tapered optical fiber probe has been recently demonstrated using fibertrodes.
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