A number of controversies in diabetes have had too little attention. I discuss the following issues: (i) drug therapy; (ii) genetics; (iii) antihypertensive treatment in patients with normoalbuminuria and with abnormal albuminuria; (iv) insulin analogs; (v) cancer in diabetes; (vi) hypophysectomy; (vii) renal biopsy; (viii) low protein diet; and (ix) glycated hemoglobin. A closer look at these items is required in order to have a more realistic picture of diabetes research. A scheme of other controversies is also provided. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00012.x, 2010).
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008022 | PMC |
http://dx.doi.org/10.1111/j.2040-1124.2010.00012.x | DOI Listing |
BMC Endocr Disord
January 2025
Department of Endocrinology and Metabolism, Fourth People's Hospital of Shenyang, Shenyang, P.R. China.
Background: Diabetes characterized by chronic hyperglycemia, has become a serious hazard to human health in the recent decades. Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis, appetite, insulin secretion, and insulin sensitivity. Although some studies have shown that asprosin levels are higher in patients with diabetes than in healthy individuals, the association between asprosin levels and diabetes remains controversial.
View Article and Find Full Text PDFWorld J Gastroenterol
January 2025
Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, Guangdong Province, China.
Background: Type II diabetes mellitus (T2DM) has been associated with increased risk of colon cancer (CC) and worse prognosis in patients with metastases. The effects of T2DM on postoperative chemoresistance rate (CRR) and long-term disease-free survival (DFS) and overall survival (OS) in patients with stage III CC who receive curative resection remain controversial.
Aim: To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III CC.
Curr Med Chem
January 2025
Laboratory of Metabolism and Gastrointestinal Tumor, Shandong Provincial QianFoShan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Introduction: Gastric cancer (GC) is the fifth most common cancer globally, and the relationship between type 2 diabetes mellitus (T2DM) and cancer risk remains controversial.
Methods: We performed Mendelian randomization (MR) analysis using publicly available GWAS data to assess the causal relationship between T2DM and GC, validated by heterogeneity and pleiotropy analyses. Transcriptomic data from TCGA and GEO were analyzed to identify common differentially expressed genes (DEGs).
Clin Med (Lond)
January 2025
Department of Applied Health, School of Health Sciences, Murray Learning Centre, College of Medicine and Health, University of Birmingham, Birmingham B15 2FG, UK. Electronic address:
Adequate control of thyroid function is crucial for optimal pregnancy outcomes and neurodevelopment of the offspring and testing for thyroid function is ideally performed using manufacturer and gestation specific reference ranges. Whilst universal screening for thyroid dysfunction is not recommended, targeted case finding of women at risk of thyroid disease during pregnancy is advised. A number of controversies continue to fuel debate including: (i) the target range for thyroid stimulating hormone (TSH) in women with subfertility planning pregnancy (ii) management of mild thyroid hypofunction before and during pregnancy (iii) the treatment of TPO-antibody positive euthyroid women with levothyroxine (iv) the optimal choice of antithyroid treatment in women with hyperthyroidism.
View Article and Find Full Text PDFOrthop J Sports Med
January 2025
Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, PR China.
Background: Although previous studies have investigated the risk factors for rotator cuff syndrome (RCS), there remains controversy due to uncontrolled and uncertain confounding factors in their analyses.
Purpose: To perform Mendelian randomization (MR) analysis using single-nucleotide polymorphisms to investigate the causal relationship between RCS and 4 risk factors: type 2 diabetes mellitus (T2DM), high blood pressure (HBP), body mass index (BMI), and low high-density lipoprotein cholesterol (HDL-C).
Study Design: Descriptive epidemiology study.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!