Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017194 | PMC |
| http://dx.doi.org/10.1016/j.mjafi.2012.07.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Public Health.
Alzheimers Dement
December 2024
University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Background: Exposures to environmental toxicants and pollutants occur at various points along the life course, with mounting evidence that late-life pollution exposure increases risk for neurological disease, including dementia. Although occupational hazards constitute a primary source of modifiable environmental exposure during the working years, there is little research examining the protracted effects of mid-life occupational exposure on late-life dementia risk.
Method: This study leveraged life course data from the Wisconsin Longitudinal Study (WLS) to evaluate the effects of mid-life occupational hazardous exposures on late-life dementia outcomes.
Developing Topics.
Alzheimers Dement
December 2024
Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Previous models of resilience to Alzheimer's Disease (AD) have relied on cross-sectional designs and inclusion of measures of neuropathology. Here, we present a novel modeling approach incorporating longitudinal data and the use of APOE and higher order interaction terms to approximate neuropathological resilience, vastly increasing participant diversity and statistical power. We validate this approach and report novel genetic associations with neuropathological resilience.
View Article and Find Full Text PDFRepair of aortic coarctation in neonates less than two kilograms.
Interdiscip Cardiovasc Thorac Surg
December 2024
Department of Cardiac Surgery, Bristol Royal Hospital for Children, University of Bristol, Bristol, UK.
Objectives: A significant number of low-birth-weight neonates are born with aortic coarctation. Previous studies of early operation on these patients have shown a high hospital mortality and recurrence at 1 year. We reviewed our data to ascertain whether modern approaches allow better outcomes for these children.
View Article and Find Full Text PDFThe Development of Heart Failure Electronic-Message Driven Tips to Support Self-Management: Co-Design Case Study.
JMIR Cardio
November 2024
National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
Background: Heart failure (HF) is a complex syndrome associated with high morbidity and mortality and increased health care use. Patient education is key to improving health outcomes, achieved by promoting self-management to optimize medical management. Newer digital tools like SMS text messaging and smartphone apps provide novel patient education approaches.
View Article and Find Full Text PDFLatent cognitive phenotypes in juvenile myoclonic epilepsy: Clinical, sociodemographic, and neuroimaging associations.
Epilepsia
November 2024
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Objective: Application of cluster analytic procedures has advanced understanding of the cognitive heterogeneity inherent in diverse epilepsy syndromes and the associated clinical and neuroimaging features. Application of this unsupervised machine learning approach to the neuropsychological performance of persons with juvenile myoclonic epilepsy (JME) has yet to be attempted, which is the intent of this investigation.
Methods: A total of 77 JME participants, 19 unaffected siblings, and 44 unrelated controls, 12 to 25 years of age, were administered a comprehensive neuropsychological battery (intelligence, language, memory, executive function, and processing speed), which was subjected to factor analysis followed by K-means clustering of the resultant factor scores.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!