AI Article Synopsis
- The study examined the link between retinal nerve fibre layer thickness (RNFL) and white matter damage in patients with multiple sclerosis (MS) using diffusion tensor imaging (DTI).
- Forty-four MS patients and 30 healthy controls were tested using optical coherence tomography and analyzed for DTI in specific brain regions, including the optic radiation and corpus callosum.
- Results showed that RNFL correlated with fractional anisotropy (FA) in multiple white matter areas, suggesting that damage in the RNFL may indicate more widespread white matter issues beyond just the visual pathway.
Article Abstract
We investigated the association of retinal nerve fibre layer thickness (RNFL) with white matter damage assessed by diffusion tensor imaging (DTI). Forty-four MS patients and 30 healthy subjects underwent optical coherence tomography. DTI was analysed with a voxel-based whole brain and region-based analysis of optic radiation, corpus callosum and further white matter. Correlations between RNFL, fractional anisotropy (FA) and other DTI-based parameters were assessed in patients and controls. RNFL correlated with optic radiation FA, but also with corpus callosum and remaining white matter FA. Our findings demonstrate that RNFL changes indicate white matter damage exceeding the visual pathway.
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| http://dx.doi.org/10.1177/1352458514535128 | DOI Listing |
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