AI Article Synopsis
- The study aimed to explore the relationship between hormone levels and hospital mortality in male patients with severe traumatic brain injury (TBI).
- A variety of hormone levels, including LH and cortisol, were measured in patients shortly after their injury, revealing that hormonal abnormalities were present in a significant number of cases.
- The findings indicated that while certain hormone levels like LH had a potential association with mortality, other hormones showed less consistency in their relation to patient outcomes, alongside indicators like pupil reactivity and Glasgow Coma Score.
Article Abstract
Introduction: Changes in hormone blood levels during the acute phase of traumatic brain injury (TBI) have been described in the literature. The objective was to investigate the association among several hormones plasma levels in the acute phase of severe TBI and the hospital mortality rate of male patients.
Methods: The independent association among plasma levels of TSH, LH, FSH, GH, free T4, cortisol, IGF-1 and total testosterone was measured 10 hours and 30 hours after severe TBI and the hospital mortality of 60 consecutive male patients was evaluated.
Results: At least one hormonal level abnormality was demonstrated in 3.6-73.1% of patients. The multiple logistic regressions showed a trend for an independent association among hospital mortality and normal or elevated LH levels measured at 10 hours (OR = 3.7, 95% CI = 0.8-16.3, p = 0.08) and 30 hours (OR = 3.9, 95% CI = 0.9-16.7, p = 0.06). Admission with abnormal pupils and a lower Glasgow Coma Score also were independently associated with hospital mortality.
Conclusion: The hormonal changes are frequent in the acute phase of severe TBI. The hormones plasma levels, excepting the LH, are not highly consistent with the hospital mortality of male patients.
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| http://dx.doi.org/10.3109/02699052.2014.915986 | DOI Listing |
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