AI Article Synopsis
- * N-Chlorophthalimide (NCP) acts as a Lewis acid that activates and oxidizes iodine (I2) to facilitate this iodolactonization process.
- * Only 0.5 equivalents of I2 are needed when combined with 1.5 equivalents of NCP to produce the required iodinating reagent for the reaction.
Article Abstract
Chiral triaryl phosphates promote the enantioselective iodolactonization of 4-substituted 4-pentenoic acids to give the corresponding iodolactones in high yields with high enantioselectivity. N-Chlorophthalimide (NCP) is employed as a Lewis acidic activator and oxidant of I2 for the present iodolactonization. In combination with 1.5 equivalents of NCP, only 0.5 equivalents of I2 are sufficient to generate the iodinating reagent.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201400946 | DOI Listing |
Publication Analysis
Top Keywords
enantioselective iodolactonization
8
cooperative activation
4
activation chiral
4
chiral nucleophilic
4
nucleophilic catalysts
4
catalysts n-haloimides
4
n-haloimides enantioselective
4
iodolactonization 4-arylmethyl-4-pentenoic
4
4-arylmethyl-4-pentenoic acids
4
acids chiral
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!