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Double C-F bond activation through β-fluorine elimination: nickel-mediated [3+2] cycloaddition of 2-trifluoromethyl-1-alkenes with alkynes. | LitMetric
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Double C-F bond activation through β-fluorine elimination: nickel-mediated [3+2] cycloaddition of 2-trifluoromethyl-1-alkenes with alkynes.

Tomohiro Ichitsuka Takeshi Fujita Tomohiro Arita Junji Ichikawa

Angew Chem Int Ed Engl

Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571 (Japan) http://www.chem.tsukuba.ac.jp/junji/index.html.

Published: July 2014

The nickel-mediated [3+2] cycloaddition of 2-trifluoromethyl-1-alkenes with alkynes afforded fluorine-containing multi-substituted cyclopentadienes in a regioselective manner. This reaction involves the consecutive two C-F bond cleavage of a trifluoromethyl or a pentafluoroethyl group through β-fluorine elimination.

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http://dx.doi.org/10.1002/anie.201402695DOI Listing

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