AI Article Synopsis
- PPAR-γ is a nuclear receptor that regulates lipid metabolism and inflammation, and this study investigates the effects of the synthetic agonist rosiglitazone on LPS-induced mastitis in rats.
- Rosiglitazone was administered before LPS injection, showing a reduction in inflammatory cell infiltration and decreased levels of inflammatory markers like TNF-α and IL-6.
- The study concludes that rosiglitazone protects against mastitis by inhibiting NF-κB signaling pathways, suggesting that PPAR-γ could be a potential therapeutic target for this condition.
Article Abstract
PPAR-γ, a member of the nuclear receptor superfamily, plays an important role in lipid metabolism and inflammation. The aim of this study was to investigate the preventive effects of synthetic PPAR-γ agonist rosiglitazone on lipopolysaccharide (LPS)-induced mastitis in rats. The mouse model of mastitis was induced by the injection of LPS through the duct of the mammary gland. Rosiglitazone was injected 1 h before the induction of LPS intraperitoneally. The results showed that rosiglitazone attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the production of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in a dose-dependent manner. Additionally, Western blotting showed that rosiglitazone inhibited the phosphorylation of IκB-α and NF-κB p65. These results indicated that rosiglitazone has a protective effect on mastitis, and the anti-inflammatory mechanism of rosiglitazone on LPS-induced mastitis in rats may be due to its ability to inhibit NF-κB signaling pathways. PPAR-γ may be a potential therapeutic target against mastitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10753-014-9924-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
S-allylmercaptocysteine inhibits TLR4-mediated inflammation through enhanced formation of inhibitory MyD88 splice variant in mammary epithelial cells.
Sci Rep
November 2024
Central Research Institute, Wakunaga Pharmaceutical Co., Ltd, 1624, Koda-cho, Akitakata-shi, Hiroshima, 739-1195, Japan.
Mastitis is an inflammatory disease affecting mammary tissues caused by bacterial infection that negatively affects milk quality and quantity. S-Allylmercaptocysteine (SAMC), a sulfur compound in aged garlic extract (AGE), suppresses lipopolysaccharide (LPS)-induced inflammation in mouse models and cell cultures. However, the mechanisms underlying this anti-inflammatory effect remain unclear.
View Article and Find Full Text PDFPaeonol attenuates LPS-induced inflammatory injury in mastitis by regulating the MAPK and Nrf2 signaling pathways.
Res Vet Sci
January 2025
College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong 271017, China; Shandong Provincial Key Laboratory of Zoonoses, Shandong Agricultural University, Taian, Shandong 271017, China; Shandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, Shandong Agricultural University, Taian, Shandong 271017, China. Electronic address:
Mastitis is an inflammatory udder disease that causes important economic losses in the animal breeding and dairy product industries. While antibiotics have contributed to disease control, their use presents risks due to drug residues in livestock products that can potentially threaten human health. Paeonol, an active ingredient extracted from the dried root bark of paeonia suffruticosa, exhibits various pharmacological effects, including anti-inflammatory and antibacterial properties, but its role in mastitis remains unclear.
View Article and Find Full Text PDFEffects of heat stress abatement on behavioral response in lactating dairy cows prior to and following an intramammary lipopolysaccharide infusion.
J Dairy Sci
November 2024
Department of Animal and Dairy Science, University of Georgia, Athens, USA, 30602. Electronic address:
The assessment of animal behavior serves as a valuable approach to identify illness and animal responses to environmental stimuli. Both heat stress and mastitis are reported to impact the behavioral responses of dairy cattle. However, little is known about the effects of heat stress on the lactating cow's behavioral responses to mastitis.
View Article and Find Full Text PDFLncRNA HULIB promotes LPS induced inflammatory response in bovine mammary epithelial cells via PP2AB.
Int Immunopharmacol
December 2024
College of Animal Science and Technology, Ningxia University, Yinchuan 750021, China. Electronic address:
Bovine mastitis is regulated by genetic and environmental factors. Long non-coding RNAs (LncRNAs), which regulate various biological processes (immune system and biological development), have been found to play a role in bovine mammary inflammation responses. Here, a novel functional lncRNA, named lncRNA HULIB, was identified as a regulator during bovine mastitis.
View Article and Find Full Text PDFColostrum-derived extracellular vesicles: potential multifunctional nanomedicine for alleviating mastitis.
J Nanobiotechnology
October 2024
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, 100193, Beijing, China.
Bovine mastitis is an infectious disease that causes substantial economic losses to the dairy industry worldwide. Current antibiotic therapy faces issues of antibiotic misuse and antimicrobial resistance, which has aroused concerns for both veterinary and human medicine. Thus, this study explored the potential of Colo EVs (bovine colostrum-derived extracellular vesicles) to address mastitis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!